Gorlin-Goltz Syndrome in a Healthy Elderly Patient: A Case Report
Gorlin-Goltz syndrome (GGS), a rare inherited autosomal dominant disorder is characterized by presence of multiple basal cell carcinomas, odontogenic keratocyst (OKCs), bifid ribs or numerous skeletal and dental anomalies. A high level of expressiveness and penetrance is shown by this entity. It is therefore, necessary to understand the major and minor diagnostic criteria for the prompt diagnosis of this condition. We hereby report a case of a 50-year-old male who presented with multiple OKCs. On carrying out further investigations, bifid ribs and calcification of falx cerebri were additional findings which lead us to the diagnosis of GGS. It is therefore necessary to consider GGS as a possible diagnosis while dealing with any case of multiple OKCs.
1. Pol CA, Ghige SK, Kalaskar RR, Gosavi SR. Gorlin-Goltz syndrome: a rare case report. Contemp Clin Dent. 2013;4(4):547-50.
2. Kiran NK, Tilak Raj TN, Mukunda KS, Reddy RV. Nevoid basal cell carcinoma syndrome (Gorlin-Goltz syndrome). Contemp Clin Dent. 2012;3(4):514-8.
3. Ramesh M, Krishnan R, Chalakkal P, Paul G. Goltz-Gorlin Syndrome: case report and literature review. J Oral Maxillofac Pathol. 2015;19(2):267.
4. Sunil MK, Kumar R, Guru EN, Ranjan V. Gorlin-Goltz Syndrome. J Indian Acad Oral Med Radiol. 2010;22(4): S58-61.
5. Al-Jarboua MN, Al-Husayni AH, Al-Mgran M, Al-Omar AF. Gorlin-Goltz syndrome: a case report and literature review. Cureus. 2019;11(1):e3849.
6. Bedi RS, Aurora JK, Chauhan H, Sayeed MS. Gorlin Goltz Syndrome – familial inheritance – a rare case series. Sch J Dent Sci. 2020;7(9):109-13.
7. Kiwilsza M, Sporniak-Tutak K. Gorlin-Goltz syndrome—a medical condition requiring a multidisciplinary approach. Med Sci Monit. 2012;18(9):RA145-53.
8. Karthiga KS, Sivapatha Sundharam B, Manikandan R. Nevoid basal cell carcinoma syndrome. Indian J Dent Res. 2006;17(1):50-3.
9. Namdeoraoji Bahadure R, Surendraji Jain E, P Badole G. Gorlin and goltz syndrome: a case report with surgical review. Int J Clin Pediatr Dent. 2013;6(2):104-8.
10. Kumar NN, Padmashree S, Jyotsna TR, Shastry SP. Gorlin-Goltz syndrome: a rare case report. Contemp Clin Dent. 2018;9(3):478-83.
11. Kimonis VE, Goldstein AM, Pastakia B, Yang ML, Kase R, DiGiovanna JJ, et al. Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome. Am J Med Genet. 1997;69(3):299-308.
12. Bree AF, Shah MR; BCNS colloquium group. Consensus statement from the first international colloquium on basal cell nevus syndrome (BCNS). Am J Med Genet A. 2011;155A(9):2091-7.
13. Alchalabi NJ, Merza AM, Issa SA. Using carnoy's solution in treatment of keratocystic odontogenic tumor. Ann Maxillofac Surg. 2017;7(1):51-6.
14. Tang JY, Mackay-Wiggan JM, Aszterbaum M, Yauch RL, Lindgren J, Chang K, et al. Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome. N Engl J Med. 2012;366(23):2180-8.
15. Lo Muzio L. Nevoid basal cell carcinoma syndrome (Gorlin syndrome). Orphanet J Rare Dis. 2008;3:32.